Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei
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چکیده
منابع مشابه
Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei
BACKGROUND Talaromyces marneffei is an opportunistic dimorphic fungus prevalent in Southeast Asia. We previously demonstrated that Mp1p is an immunogenic surface and secretory mannoprotein of T. marneffei. Since Mp1p is a surface protein that can generate protective immunity, we hypothesized that Mp1p and/or its homologs are virulence factors. METHODOLOGY/PRINCIPAL FINDINGS We examined the pa...
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Talaromyces (Penicillium) marneffei is an important opportunistic fungal pathogen. It causes disseminated infection in immunocompromised patients especially in Southeast Asian countries. The pathogenicity of T. marneffei depends on the ability of the fungus to survive the killing process and replicate inside the macrophage. Major stresses inside the phagosome of macrophages are heat, oxidative ...
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ژورنال
عنوان ژورنال: PLOS Neglected Tropical Diseases
سال: 2016
ISSN: 1935-2735
DOI: 10.1371/journal.pntd.0004907